Convenient synthesis of the pentasaccharide repeating unit corresponding to the cell wall O-antigen of Escherichia albertii O4

• Tapasi Manna,
• Arin Gucchait and
• Anup Kumar Misra

Beilstein J. Org. Chem. 2020, 16, 106–110, doi:10.3762/bjoc.16.12

• corresponding to the cell wall O-antigen of the Escherichia albertii O4 strain in very good yield with the desired configuration at the glycosidic linkages using thioglycosides and trichloroacetimidate derivatives as glycosyl donors and perchloric acid supported over silica (HClO4/SiO2) as a solid supported

• protic acid glycosyl activator. The expected configuration at the glycosidic linkages was achieved using a reasonable selection of protecting groups in the manosaccharide intermediates. Keywords: Escherichia albertii O4; glycosylation; HClO4/SiO2; O-antigen; pentasaccharide; Introduction Diarrheal

• pentasaccharide repeating unit of the cell wall O-antigen of Escherichia albertii O4 in very good yield. Although the target compound can be achieved by block synthetic approach but a better yield of the product was obtained by a sequential approach. HClO4/SiO2 was used as a solid acid activator in the